MetaboXL Thin 90 Review

MetaboXL Thin 90 is an advanced weight loss fat burner formula, comes packed with Amazonian Guarana extract and is our #1 ranked diet pill.   

Our research found that Guarana is widely used as a stimulant, and promotes advanced weight loss through the interplay of several active compounds that appear to :

– Increase fat oxidation, the body’s usage of fat for energy

– Raise energy expenditure through thermogenic (heat-generating) effects

– Enhance exercise performance; guarana is a potential ergogenic aid

The guarnine (a stimulant similar to caffeine) in guarana can make it useful for boosting energy levels, reducing the appetite, revving up the metabolism, and for a number of other benefits that can be handy for someone who is following a reduced calorie diet and who needs to have the drive to complete regular exercise routines.

Guarana (Paullinia cupana) is a tropical plant found in Brazil, which has been used for thousands of years by tribes in the Amazon for its medicinal effects. Guarana seeds are known for their high caffeine content (3-7%) – about twice of that found in coffee beans.

As a result, its use parallels that of caffeine. Guarana is a popular ingredient in dietary supplements and is used to help with a number of ailments ranging from low blood pressure to headaches. Guarana is also commonly used in weight loss aids, and may have some alertness-enhancing properties that, while not truly nootropic, may help to energize cognitive function.

However, it may be more effective than caffeine alone because Guarana contains other compounds that may also be beneficial for weight loss – small amounts of theobromine, theophylline and catechins, as well as high tannin content (5-8.5%).

• Caffeine, theobromine and theophylline are all methylxanthines – compounds that are known for their stimulating effects. Meanwhile, catechins and tannins are polyphenols – organic compounds found in plants that have a number of health benefits.

Metabo Thin XL 90 Guarana’s Potential Fat-Burning Bio-Activities

Guarana is believed to aid weight loss through the combined biological activities of 5 key components:

– Caffeine

– Theobromine

– Theophylline

– Tannins

– Catechins.

Metabo XL Thin 90 Fat Oxidation & Metabolism Support

Caffeine – Guarana’s major active ingredient – is believed to aid weight loss through 3 main actions: increasing fat oxidation (the body’s usage of fat for energy), enhancing metabolism by increased energy expenditure, and enhancing the effectiveness of exercise.

These effects are achieved through a number of complex mechanisms which include:

• Inhibition of the enzyme phosphodiesterase
• Blockade of receptors for adenosine, a compound responsible for suppressing lipolysis (fat breakdown)
• Countering sleepiness and increasing serotonin and dopamine levels, neurotransmitters associated with happiness and well-being.

Meanwhile, research shows that both theophylline and theobromine are believed to function similarly to caffeine, since they belong to the same group of stimulant compounds.

Metabo XL Thin 90 Possible Fat-Binding Activity

Tannins may also possibly play a role in Guarana’s bio-activity, but few human trials have been done. Studies in animals suggest that tannins may aid in weight loss by binding proteins and carbohydrates into indigestible forms, and also by directly binding to digestive enzymes.

Metabo XL Thin 90 Energy Expenditure

Finally, catechins may also play a role in Guarana’s bio-activities by enhancing energy expenditure and fat oxidation, similar to caffeine. They are believed to work by inhibiting the enzyme COMT, which plays a role in degradation of catecholamines – compounds such as epinephrine that play a role in regulating fat tissue, and also by inhibiting several enzymes used to digest fat.

Refernces:

• Heckman MA. et al. Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. J Food Sci. 2010 Apr;75(3):R77-87
• Andersen T. and Fogh J. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J Hum Nutr Diet. 2001 Jun;14(3):243-50.
• Hursel R. et al. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes Rev. 2011 Jul;12(7):e573-81
• Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807.
• Belza A, Toubro S, Astrup A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eur J Clin Nutr. 2009 Jan;63(1):57-64
• Martínez-Pinilla E. Oñatibia-Astibia A, Franco R. The relevance of theobromine for the beneficial effects of cocoa consumption. Front Pharmacol. 2015; 6: 30.
• Peters EJ, Klein S, Wolfe RR. Effect of short-term fasting on the lipolytic response to theophylline. Am J Physiol. 1991 Oct;261(4 Pt 1):E500-4.
• Awika JM, Rooney LW. Sorghum phytochemicals and their potential impact on human health. Phytochemistry. 2004 May;65(9):1199-221.
• Nagao T. et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr. 2005 Jan;81(1):122-9.
• Awika JM, Rooney LW. Sorghum phytochemicals and their potential impact on human health. Phytochemistry. 2004 May;65(9):1199-221.
• Lima WP. et al. Lipid metabolism in trained rats: effect of guarana (Paullinia cupana Mart.) supplementation. Clin Nutr. 2005 Dec;24(6):1019-28.
• Bérubé-Parent S. et al. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br J Nutr. 2005 Sep;94(3):432-6.
• Krewer Cda C. et al. Habitual intake of guaraná and metabolic morbidities: an epidemiological study of an elderly Amazonian population. Phytother Res. 2011 Sep;25(9):1367-74.
• Nagao T. et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr. 2005 Jan;81(1):122-9.
• De la Garza AL. et al. Natural Inhibitors of Pancreatic Lipase as New Players in Obesity Treatment. Planta Med. 2011 May;77(8):773-85